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Nutrition

Dietary SupplementsWhat They Are, Benefits, Safety Precautions

Given the ever-growing buzz around dietary supplements, it can be difficult to know what the benefits really are. By learning more about vitamins, minerals, and other supplements, you can make safer choices about what’s right for you.

A woman with dietary supplements in her hand, illustrating a moment of contemplation regarding her health choices.

What are dietary supplements?

The Food and Drug Administration (FDA) defines a dietary supplement as a product you take to add nutritional value to your diet. It contains a dietary ingredient, which may be one or a combination of the following:

  • Vitamins.
  • Minerals.
  • Herbs or other botanicals.
  • Amino acids.
  • Concentrates, metabolites, constituents, or extracts.

There are various types of supplements, each serving a different purpose. Vitamins and minerals are essential nutrients that play multiple roles in body function, including physical and mental health. Herbal and botanical supplements are derived from plants and used for medicinal purposes. Whole food supplements are made from concentrated, minimally processed foods and aim to provide nutrients in their natural form.

Supplements can take various forms, including tablets, capsules, soft gels, gel caps, liquids, or powders.

We’re always hearing how a certain vitamin or herbal supplement will cure a chronic condition or drastically improve the quality of our lives. However, information about dietary supplements is often confusing or unclear. It’s hard to know which offer genuine health benefits and which are merely giving false promises, or worse, running the risk of actually damaging your health.

By learning all you can about vitamins and supplements, you can make better choices about those that are right for you or your family.

Types of dietary supplements

Micronutrients—vitamins and minerals

Vitamins and minerals are essential nutrients your body needs to function correctly. The term “essential” means your body cannot produce these on its own and must get them from food sources or supplements.

Some common vitamins and minerals to know and their role in the body include:

  • Vitamin A supports vision and immune function.
  • B vitamins play a role in metabolism, cell function, nerve functions, and DNA production and repair.
  • Vitamin C supports immune function and assists in iron absorption.
  • Vitamin D is essential for bone health and immune function.
  • Vitamin E supports immune function and protects the body’s cells.
  • Vitamin K plays a role in blood clotting and bone health.
  • Calcium supports bones, teeth, and muscle function.
  • Phosphorus is essential for bone and teeth formation and DNA production.
  • Potassium and sodium play a role in fluid balance and muscle function.
  • Magnesium is essential for muscle and nerve function and bone health.
  • Iron is needed to transport oxygen throughout the body.
  • Zinc supports immune function and wound healing.
  • Copper is used in nervous system functions.
  • Selenium plays a role in thyroid and immune function.
  • Iodine is needed for thyroid hormone production.

Vitamin and mineral deficiency can impair your body’s ability to heal and protect itself. However, micronutrient supplements should be seen as a complement to a healthy diet rather than a “fix” for an unhealthy one. Eating a balanced, varied diet rich in fresh fruits, vegetables, whole grains, lean proteins, and healthy fats and low in processed, fried, sugary, and refined foods is the best way to ensure you’re consuming the vitamins and minerals your body needs.

The additional nutrients found in supplements, or a general multivitamin and mineral supplement, may serve as an option to help you overcome periodic nutrient shortfalls in your diet.

Herbal and botanical supplements

Herbal and botanical supplements are made from plants or plant parts and are used for medicinal or therapeutic purposes. Some people may use them to prevent certain diseases or to help treat existing conditions. They differ from vitamins and minerals in that they are considered to have medicinal value. Before Western medicine, traditional therapies used herbs to prevent and heal specific ailments.

Some commonly known herbs and their suggested benefits include:

  • Ashwagandha may support sleep quality and stress management.
  • Echinacea may play a role in immune function.
  • Ginkgo biloba may support cognitive function.
  • Turmeric’s active ingredient, curcumin, may help reduce inflammation and support joint health. Including black pepper (sometimes listed as piperine on a supplement label) allows your body to better benefit from the curcumin.
  • St John’s Wort may support mental health as it relates to depression and anxiety.
  • Ginseng may play a role in cognitive function.
  • Valerian root may support sleep quality and mental health.
  • Saw Palmetto may support prostate health.
  • Elderberry may play a role in immune function.
  • Peppermint may support the digestive system.
  • Chamomile may support sleep quality and mental health.
  • Ginger may play a role in digestion and reducing nausea.
  • Green tea may support immune function and cognitive function.

Before taking a new herbal supplement, though, you’ll want to consult with your doctor. Some herbal supplements can interact with over-the-counter medications or prescription drugs and cause adverse side effects. Though an herbal supplement is extracted from a “natural” source, it may still be as potent as any other medication you take.

Whole food supplements

Whole food supplements are made from whole food sources and typically provide the same nutrients as their whole food sources—vitamins, minerals, antioxidants, phytonutrients, or bioactive compounds. Unlike conventional vitamin and mineral supplements, they are non-synthetic and made from concentrated, minimally processed whole foods.

Some commonly known whole food supplements include:

  • Greens powders that include ingredients like spirulina, chlorella, wheatgrass, or barley grass.
  • Fruit and vegetable powders.
  • Probiotics.
  • Omega-3 fish oils.
  • Protein powders, both animal and plant-based.
  • Fiber supplements.
  • Mushroom blends.

Some researchers believe nutrients from whole-food supplements are better absorbed and more efficiently used in the body than synthetic, conventional supplements. However, there needs to be more evidence to make claims about this. There may be instances where whole-food supplements are more appropriate, and synthetic vitamin and mineral supplements may be recommended at other times.

As with any supplement, seeking guidance from a doctor or registered dietitian is recommended to help identify which supplements may be appropriate and safe for you to consume.

Supplement benefits

In many cases, supplements can significantly add to your overall dietary intake. While dietitians recommend that you try to get your essential nutrients from the food you eat, supplements may be necessary to support health goals at certain times. For example, you may benefit from taking a supplement if you:

  • Are a woman of childbearing age.
  • Are pregnant or lactating or seeking to become pregnant.
  • Are post-menopausal.
  • Are a child or teen with irregular eating habits.
  • Are an older adult.
  • Are highly active.
  • Are on a restricted diet, such as a vegetarian or vegan, are a picky eater, have a food allergy, or are avoiding certain food groups.
  • Have an eating disorders or disordered eating patterns
  • Have a chronic medical condition, injury, or are recovering from surgery.
  • Have a limited sun exposure.
  • Take medications that deplete nutrients, such as corticosteroids.
  • Are chronically stressed.

If you have a restricted diet or trouble eating a variety of foods, you may benefit from a multivitamin. In other circumstances, you may benefit more from a more specific nutrient, such as vitamin D if you get limited sun exposure, folic acid, iron, and calcium if you’re prenatal or pregnant, or protein, vitamin D, and calcium if you’re an older adult. While supplementation may enhance your overall dietary intake, it isn’t a substitute for a varied and balanced diet.

Which supplements do you need?

As noted, supplements are never intended as a substitute for a healthy, balanced diet. However, some people may benefit from a single supplement, while others may need more than one to achieve their health goals. How long you need to take a supplement can also vary. You may benefit from ongoing supplementation or just need extra nutrients for a short time.

Below is a list of commonly used supplements, who may benefit from them, and their considerations.

Multivitamin

You may benefit from taking a multivitamin if you have a restrictive diet, a nutrient deficiency, are pregnant, looking to become pregnant, or have a specific health condition like anemia or osteoporosis.

You’re less likely to need a multivitamin if you eat a varied and balanced diet, have no chronic illness, or have a health condition where specific nutrients should be limited (such as iron or vitamin D).

Multivitamins may help prevent nutrient deficiencies or fill nutrient gaps that are not filled through your diet. But you need to make sure you don’t over-supplement, as that can interact with certain medications, or may even be toxic.

Vitamin B12

B12 is naturally found in animal foods as well as products such as nutritional yeast, fortified cereals, and fortified plant milk. If you follow a vegan or vegetarian diet, have pernicious anemia, or are vitamin B12 deficient, you may benefit from supplementing with vitamin B12.

Be sure to consult with a doctor or registered dietitian to make sure you take an appropriate dose as over-supplementing with vitamin B12 can lead to headache, nausea, vomiting, or diarrhea.

Vitamin C

Vitamin C is found in various fruits and vegetables, including citrus fruits, tomatoes, bell peppers, and broccoli. Supplementation may be recommended if you don’t eat or don’t have access to a variety of fruits and vegetables, if you are immunocompromised, or if you smoke.

While taking vitamin C supplements may not prevent the common cold, as many believe, it may shorten the length of the cold. High doses may cause stomach upset or diarrhea, but vitamin C is generally safe to consume at recommended amounts. If you are taking statins or going through chemotherapy treatments, you should avoid taking vitamin C supplements.

Vitamin D

Essential for bone health and immune function, the primary source for vitamin D comes from the sun. It can also be found in certain types of fish and fortified dairy products. Data suggests that Vitamin D deficiency is prevalent in the United States, especially in winter. You may benefit from a vitamin D supplement if you are an older adult, have a darker skin tone, have osteoporosis or a bone fracture or break, don’t spend much time outside, or are living at a latitude above 37 degrees north or below 37 degrees south of the equator.

Again, it’s important to keep vitamin D supplementation within recommended limits as high doses could lead to toxicity.

Calcium

Calcium is found in dairy foods, dark leafy greens, nuts, and seeds. You may benefit from a calcium supplement if you are postmenopausal, have osteoporosis, or are healing from a bone fracture or break.

You should avoid calcium supplements if you have high calcium levels or are prone to getting kidney stones. Calcium supplementation should also be avoided if you take blood thinners or certain heart or cancer medications.

Iron

Food sources rich in iron include meat, legumes, nuts and seeds, and dark leafy greens. You should likely supplement with iron if you have anemia or low iron stores or are prenatal, pregnant, or breastfeeding. Supplementation may also be required if you have heavy menstrual periods, are a frequent blood donor, or have certain gastrointestinal disorders.

Iron supplements can negatively interact with antibiotics, thyroid medication, and bisphosphonates (a type of medication used to treat bone diseases). While iron supplementation is highly effective in treating anemia and low iron stores, high doses may cause gastrointestinal issues like upset stomach, constipation, and nausea.

Eating vitamin C rich foods or taking a vitamin C supplement with your iron supplement can help you better absorb the iron. However, iron supplements should not be taken right after exercise because absorption may drop significantly. If you are taking iron supplements, calcium-containing foods and supplements should be taken two or more hours before or after iron supplementation.

Magnesium

Magnesium can be found in whole grains, dark leafy greens, legumes, nuts and seeds, and dark chocolate. In recent years, magnesium has become more popular for its potential benefits in alleviating migraines, muscle cramps, hot flashes, and constipation, and improving sleep. While these benefits sound great, there still needs to be more research to confirm these potential benefits. You should avoid taking magnesium supplements if you have kidney disease or are taking antibiotics, magnesium-containing antacids, certain diuretics, or blood thinners.

Zinc

Zinc is found in meat, shellfish, legumes, nuts and seeds, and dairy. Zinc plays a role in immunity and wound healing and has been shown to help improve chronic diarrhea. If you have celiac disease or inflammatory bowel disease, you may be at an increased risk for zinc deficiency and may benefit from taking zinc supplements.

Your doctor will likely advise you to avoid taking zinc supplements if you are taking blood pressure medications, diuretics, or antibiotics.

Vitamin B9/folic acid/folate

Folic acid is the synthetic form of folate, the B9 vitamin largely found in green vegetables and legumes. Folic acid is more stable than folate so is often used in supplements and fortified foods. However, your body can use folate faster than folic acid, which needs to be converted into another form to be used. If you are trying to get pregnant or are already pregnant, it may be useful to take folic acid to prevent neural tube defects, like spina bifida, in babies.

Folic acid supplements are generally safe to take, but high doses may hide a vitamin B12 deficiency. Certain mutations of the MTHFR gene can also interfere with how your body processes folic acid.

Probiotics

Probiotics are living microorganisms or bacteria naturally found in the gut and consumed through foods like yogurt, kefir, kombucha, kimchi, sauerkraut, and tempeh. Probiotics play a role in gut, immune, and mental health. There are numerous strains of probiotics, and as research continues to evolve, we learn more about the benefits of individual strains.

Probiotic supplementation can be effective if a symptom-targeted approach is taken, meaning you take a supplement with the correct strain to resolve the symptom you’re experiencing. Probiotic supplements containing lactobacillus and bifidobacterium species are generally safe to take.

Minor side effects, like gas, may occur. If you have a compromised immune system, you may be at risk for more severe side effects and should only take probiotics under the supervision of your doctor or registered dietitian.

Fiber supplements

Fiber is a type of carbohydrate found in whole grains, legumes, fruits and vegetables, and nuts and seeds. It is necessary for digestive and heart health and plays a role in diabetes and cancer prevention.

Fiber supplements may help you improve bowel regularity but can interact with cholesterol-lowering drugs, warfarin, and some antidepressants. Fiber also requires fluid to get through the gastrointestinal tract, so it’s crucial to drink enough fluid with fiber supplements.

Fish oil/omega-3s

Fish oils are rich in omega-3 fatty acids, an anti-inflammatory nutrient found in foods like salmon, olives, avocados, nuts, and seeds. Omega-3 fatty acids help reduce the risk of heart disease, protect against concussions and dementia, and improve joint pain and inflammation.

You may benefit from an omega-3 supplement if you don’t like fish, have a seafood allergy, or are a strict vegetarian or vegan. If you are pregnant or looking to become pregnant, you may benefit from taking an omega-3 supplement if it’s not already in your prenatal supplement.

Protein

Protein is found in various animal and plant foods. Protein supplements come in the form of a bar or powder and are usually made with whey, casein, pea, hemp, soy, or brown rice proteins.

Protein supplements are generally considered safe to consume and can be highly effective in building and maintaining muscle mass when paired with an adequate diet and resistance training. Be sure to choose a clean protein supplement with minimal added ingredients, and no artificial sweeteners or colors. You should refrain from taking protein supplements if you have kidney disease.

Collagen

Collagen is found in bone broth, chicken skin and bone, and fish skin, bones, and scales. It is naturally made in your body, but you make less collagen as you age. In recent years, collagen has been a popular supplement if you’re seeking hair, skin, and nail health.

Collagen supplements may improve skin elasticity, reduce joint pain, and support tissue health. Collagen is generally safe to consume, but some may experience mild digestive discomfort.

Supplement safety: risks and considerations

Dietary supplements can be attractive solutions for improving your overall health or correcting or preventing nutritional imbalances. In 2020, 50 percent of Americans regularly took at least one dietary supplement, and that number has only grown since. After 2020, supplement intake around the globe increased by 23 percent. Supplements may be warranted in many circumstances, but it’s important to note they are not always risk-free and should be viewed as a potential aid, not a fix, to a problem.

Before you decide to take a supplement, ask yourself:

  1. What is my rationale for taking this supplement (do I really need it)?
  2. Can I change anything in my diet or lifestyle to better achieve my goals?
  3. Do I know this supplement is safe to consume?
  4. Do I know if this supplement works?
  5. Does this supplement negatively interact with any food or medications I consume?
  6. Do I understand the appropriate dose to take?
  7. Can I afford this supplement for the duration I need to take it?

You should take extra caution in choosing a supplement if you are a child or teen, a woman looking to get pregnant or are already pregnant or breastfeeding, immunocompromised, or have a chronic disease.

Potential side effects and interactions

It is important to take caution when beginning to take a new supplement to avoid an adverse reaction. Supplements often contain active ingredients, and side effects are more common if you consume them in large amounts or take them with medication or in combination with other supplements.

Consult with your doctor or registered dietitian to ensure you avoid any adverse reactions or toxic levels of nutrients.

Common supplement-drug interactions include:

  • Vitamin C and vitamin E may reduce the effectiveness of some types of chemotherapy.
  • Vitamin K can reduce the effectiveness of blood thinning medications.
  • St John’s wort can reduce the effectiveness of some antidepressants, heart medications, transplant drugs, and birth control pills.
  • Coenzyme Q10 can interact with anticoagulants, blood pressure medication, and chemotherapy drugs.
  • Ginkgo biloba and vitamin E can increase the risk of internal bleeding when taken with aspirin or anticoagulants such as warfarin.
  • Ginseng can also increase the risk of internal bleeding when taken with anticoagulants or NSAIDs and may cause side effects when taken with certain antidepressants.
  • Echinacea can change how the body breaks down certain medications in the liver.
  • Saw palmetto can interact with anticoagulants and NSAID pain relievers.

When considering a dietary supplement, be aware that common food products, like grains and dairy, are often fortified with vitamins and minerals to ensure you get adequate essential nutrients. Breakfast cereals are commonly fortified with iron, milk with vitamins A and D, nut milk with calcium, and grain products with folic acid. Be cautious when combining various food and supplement products to avoid consuming toxic levels of nutrients.

Toxicity

When consumed in excess, some nutrients can cause toxicity and have unpleasant or dangerous side effects.

  • Iron toxicity can cause nausea, vomiting, diarrhea, low blood pressure, liver failure, lung injury, even death.
  • Calcium – nausea, vomiting, impaired kidney function, and irregular heartbeat.
  • Vitamin D toxicity can cause high levels of calcium in the blood, which can lead to nausea, vomiting, impaired kidney function, and irregular heartbeat.
  • Vitamin A – nausea, vomiting, dizziness, blurred vision, increased risk for fractures and osteoporosis, and congenital disabilities.
  • Folic acid – may increase cancer risk and cause nausea and abdominal cramps, and hide a vitamin B12 deficiency.

Misleading claims and marketing

The global supplement industry’s estimated worth reached $152 billion in 2021. Supplement developers and companies are eager to be a part of this lucrative industry, so it’s important to avoid getting caught up in flashy marketing campaigns that promise unrealistic health benefits.

Although supplements (and their claims) don’t need to be pre-approved before hitting the market, in the United States the FDA still has specific regulations supplement companies must follow. A supplement’s label or advertisements cannot claim or imply its ability to prevent, treat, or cure a disease, nor can it be suggested to replace a food or meal. However, a dietary supplement’s label may contain one of these three claims:

  1. Health claims describe the relationship between a supplement and the reduced risk of a disease or health condition. For example, the label on a bottle of Evening Primrose Oil capsules might claim that the product “Provides relief from symptoms associated with PMS and menopause such as cramps, hot flashes, breast tenderness, and moodiness.”
  2. Nutrient content claims describe the percentage of daily value of the supplement’s nutrient.
  3. Structure/function claims describe how a nutrient or supplement ingredient affects the function of the body, but they cannot mention a specific disease. For example, “calcium builds strong bones” or “fiber maintains bowel regularity” meet this criterion, but “calcium prevents osteoporosis” or “fiber improves irritable bowel syndrome” does not.

If a manufacturer makes one of these claims, they must notify the FDA within the first 30 days of marketing the supplement. The label must also display a disclaimer that the FDA has not evaluated the claim and that the supplement is not intended to “diagnose, treat, cure, or prevent any disease.”

How to choose supplements

If you are interested in taking a supplement, first establish your reason for taking it. What are you trying to prevent, achieve, or resolve? The amount of information available on supplements can be overwhelming, but there are a few steps you can take to be confident in your choice.

  1. Seek professional guidance: Consult a doctor or registered dietitian to assess your needs and whether supplementation is appropriate.
  2. Safety and efficacy: Identify a reputable brand that makes safe supplements. The National Institute of Health Office of Dietary Supplements offers fact sheets on most dietary supplements, including safety aspects.
  3. Dosage: Identify the recommended and safe dose to take. The Mayo Clinic offers a searchable database of supplements. It rates a supplement’s efficacy for various health conditions, explains safety concerns, and provides recommended dosage information for adults and children.
  4. Third-party testing: Look for “standardized” products from manufacturers participating in the US Pharmacopeia’s Dietary Supplement Verified Program, Banned Substances Control Group, or those carrying the NSF International or Informed Choice mark of safety. Supplements are not regulated like food or prescription medication. While manufacturers must follow specific regulations, they are not required to provide evidence of product safety and efficacy or obtain approval before marketing.

A seal from a third-party testing organization can help indicate that a dietary supplement has met specific manufacturing standards, such as uniformity, cleanliness, and freedom from toxic contaminants, pesticides, heavy metals, and other substances.

There are countless supplement companies and products on the market. Quality matters, so be sure to read the ingredients and any warnings or claims on the bottle as well as much independent research as possible. Using the above tips and discussing your needs with a health professional can help you make safer and more prudent supplement choices, protecting your health and well-being.

Last updated or reviewed on September 27, 2024